Genome-wide pathway analysis in glioma
نویسندگان
چکیده
منابع مشابه
Genome-wide Association Study to Identify Genes and Biological Pathways Associated with Type Traits in Cattle using Pathway Analysis
Extended Abstract Introduction and Objective: Type traits describing the skeletal characteristics of an animal are moderately to strongly genetically correlate with other economically important traits in cattle including fertility, longevity and carcass traits. The present study aimed to conduct a genome wide association studies (GWAS) based on gene-set enrichment analysis for identifying the ...
متن کاملPredicting CpG Islands and DNA Methlation in the Cow Genome Using DNA Microarray Meta-Analysis and Genome Wide Scanning
DNA methylation is a type of epigenetic changes that directly affects DNA. In mammals, DNA methylation is essential for fetal development and stem cell differentiation and this phenomenon essentially occurs within the CpG islands. In this study, two methods were used to study the DNA methylation profile of cow genome. In the first method, the DNA methylation profile of the differentially expres...
متن کاملA pathway analysis method for genome-wide association studies.
For genome-wide association studies, we propose a new method for identifying significant biological pathways. In this approach, we aggregate data across single-nucleotide polymorphisms to obtain summary measures at the gene level. We then use a hierarchical Bayesian model, which takes the gene-level summary measures as data, in order to evaluate the relevance of each pathway to an outcome of in...
متن کاملPathway analysis of genome-wide association studies on rheumatoid arthritis.
OBJECTIVES The aims of this study were to identify candidate single nucleotide polymorphisms (SNPs) and candidate mechanisms of RA and generate hypotheses for SNP 'gene' pathways. METHODS We used a meta-analysis dataset of rheumatoid arthritis (RA) genome-wide association studies (GWAS) which included 2,554,714 SNPs in 5,539 RA cases and 20,169 controls of European descent. ICSNPathway (Ident...
متن کاملIntegrated genome-wide pathway association analysis with INTERSNP.
OBJECTIVES Pathway association analysis (PAA) tests for an excess of moderately significant SNPs in genes from a common pathway. METHODS We present a Monte-Carlo simulation framework that allows to formulate the main ideas of existing PAA approaches using a self-contained rather than a competitive null hypothesis. A stand-alone implementation in INTERSNP makes time-consuming communication wit...
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ژورنال
عنوان ژورنال: Neoplasma
سال: 2015
ISSN: 1338-4317
DOI: 10.4149/neo_2015_028